Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors
نویسندگان
چکیده
منابع مشابه
Group 1 mGluR-dependent synaptic long-term depression (mGluR-LTD): mechanisms and implications for circuitry & disease
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions including the neocortex, hippocampus, midbrain, striatum and cerebellum. Here we focus on mG...
متن کامل1 mGluR 1 , but
Abbreviated title: mGluR1-mediated modulation of neuronal excitability Number of words in the Abstract: 298 Number of text pages: 25 Abstract The modulation of neuron excitability by group I metabotropic glutamate receptors (mGluRs) was studied in isolated lamprey spinal cord neurons. At resting potential, application of the group I mGluR agonist (R, S)-3,5-dihydroxyphenylglycine (DHPG) slightl...
متن کاملAstrocytic group I mGluR dependent potentiation of astrocytic glutamate
34 One of the most important functions of astrocytes is removal of glutamate released 35 during synaptic transmission. Surprisingly, the mechanisms by which astrocyte 36 glutamate uptake is acutely modulated remain to be clarified. Astrocytes express 37 metabotropic glutamate and other G protein-coupled receptors (GPCRs) which are 38 activated during neuronal activity. Here we test the hypothes...
متن کاملPostsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region.
Activation of metabotropic glutamate receptors (mGluRs) with the group I mGluR selective agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) induces a long-term depression (LTD) of excitatory synaptic transmission in the CA1 region of the hippocampus. Here we investigated the potential roles of pre- and postsynaptic processes in the DHPG-induced LTD at excitatory synapses onto hippocampal pyramidal...
متن کاملGroup 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the neocortex, hippocampus, midbrain, striatum, and cerebellum. Here we focus on ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-84943-x